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stat.AP2025
A unified approach to spatial domain detection and cell-type deconvolution in spot-based spatial transcriptomics
Hyun Jung Koo, Aaron J. Molstad
Popular technologies for generating spatially resolved transcriptomic data measure gene expression at the resolution of a "spot", i.e., a small tissue region 55 microns in diameter…
stat.AP2024
Smooth and shape-constrained quantile distributed lag models
Yisen Jin, Aaron J. Molstad, Ander Wilson +1
Exposure to environmental pollutants during the gestational period can significantly impact infant health outcomes, such as birth weight and neurological development. Identifying c…
stat.AP2024
Heterogeneity-aware integrative regression for ancestry-specific association studies
Aaron J. Molstad, Yanwei Cai, Alexander P. Reiner +3
Ancestry-specific proteome-wide association studies (PWAS) based on genetically predicted protein expression can reveal complex disease etiology specific to certain ancestral group…