The free energy landscape of GABA binding to a pentameric ligand-gated ion channel and its disruption by mutations

Federico Comitani, Vittorio Limongelli, Carla Molteni

Pentameric ligand-gated ion channels (pLGICs) of the Cys-loop superfamily are important neuroreceptors that mediate fast synaptic transmission. They are activated by the binding of…