4 papers
A Brief History of Digital Twin Technology
Yunqi Zhang, Kuangyu Shi, Biao Li
Emerging from NASA's spacecraft simulations in the 1960s, digital twin technology has advanced through industrial adoption to spark a healthcare transformation. A digital twin is a…
Mathematical and Computational Nuclear Oncology: Toward Optimized Radiopharmaceutical Therapy via Digital Twins
Marc Ryhiner, Yangmeihui Song, Babak Saboury +3
This article presents the general framework of theranostic digital twins (TDTs) in computational nuclear medicine, designed to support clinical decision-making and improve cancer p…
An Overview of Physiologically Based Pharmacokinetic (PBPK) and Population Pharmacokinetic (PopPK) Models
Deni Hardiansyah, Bisma Baron Patrianesha, Kuangyu Shi +3
This review discusses the current applications, advantages, and limitations of PBPK and PopPK models in radiopharmaceutical therapy (RPT). PBPK models simulate radiopharmaceutical…
Artificial intelligence for simplified patient-centered dosimetry in radiopharmaceutical therapies
Alejandro Lopez-Montes, Fereshteh Yousefirizi, Yizhou Chen +8
KEY WORDS: Artificial Intelligence (AI), Theranostics, Dosimetry, Radiopharmaceutical Therapy (RPT), Patient-friendly dosimetry KEY POINTS - The rapid evolution of radiopharmaceuti…