3 papers
cond-mat.soft2025
Thermodynamic Basis of Sugar-Dependent Polymer Stabilization: Informing Biologic Formulation Design
Praveen Muralikrishnan, Jonathan W. P. Zajac, Caryn L. Heldt +2
The stabilization of macromolecules is fundamental to developing biological formulations, such as vaccines and protein therapeutics. In this study, we employ coarse grained polymer…
cond-mat.soft2024
Impact of Co-Excipient Selection on Hydrophobic Polymer Folding: Insights for Optimal Formulation Design
Jonathan W. P. Zajac, Praveen Muralikrishnan, Caryn L. Heldt +2
The stabilization of liquid biological products is a complex task that depends on the chemical composition of both the active ingredient and any excipients in solution. Frequently,…
cond-mat.soft2024
Flipping Out: Role of Arginine in Hydrophobic Interactions and Biological Formulation Design
Jonathan W. P. Zajac, Praveen Muralikrishnan, Idris Tohidian +4
Arginine has been a mainstay in biological formulation development for decades. To date, the way arginine modulates protein stability has been widely studied and debated. Here, we…