43 citations · 69 across the 4 of their papers we have counts for
6 papers
Improving the Hole Picture: Towards a Consensus on the Mechanism of Nuclear Transport
David Cowburn, Michael Rout
Nuclear pore complexes (NPCs) mediate the exchange of materials between the nucleoplasm and cytoplasm, playing a key role in the separation of nucleic acids and proteins into their…
NMR Assignment through Linear Programming
Jose F. S. Bravo-Ferreira, David Cowburn, Yuehaw Khoo +1
Nuclear Magnetic Resonance (NMR) Spectroscopy is the second most used technique (after X-ray crystallography) for structural determination of proteins. A computational challenge in…
Deciphering the 'fuzzy' interaction of FG nucleoporins and transport factors using SANS
Samuel Sparks, Deniz B. Temel, Michael P. Rout +1
The largely intrinsically disordered phenylalanine-glycine-rich nucleoporins (FG Nups) underline a selectivity mechanism, which enables the rapid translocation of transport factors…
Bias Correction in Saupe Tensor Estimation
Yuehaw Khoo, Amit Singer, David Cowburn
Estimation of the Saupe tensor is central to the determination of molecular structures from residual dipolar couplings (RDC) or chemical shift anisotropies. Assuming a given templa…
Integrating NOE and RDC using sum-of-squares relaxation for protein structure determination
Yuehaw Khoo, Amit Singer, David Cowburn
We revisit the problem of protein structure determination from geometrical restraints from NMR, using convex optimization. It is well-known that the NP-hard distance geometry probl…
Eigenvector Synchronization, Graph Rigidity and the Molecule Problem
Mihai Cucuringu, Amit Singer, David Cowburn
The graph realization problem has received a great deal of attention in recent years, due to its importance in applications such as wireless sensor networks and structural biology.…