6 papers
Integrated Transcriptomic-proteomic Biomarker Identification for Radiation Response Prediction in Non-small Cell Lung Cancer Cell Lines
Yajun Yu, Guoping Xu, Steve Jiang +4
To develop an integrated transcriptome-proteome framework for identifying concurrent biomarkers predictive of radiation response, as measured by survival fraction at 2 Gy (SF2), in…
Leveraging Support Vector Regression, Radiomics and Dosiomics for Outcome Prediction in Personalized Ultra-fractionated Stereotactic Adaptive Radiotherapy (PULSAR)
Yajun Yu, Steve Jiang, Robert Timmerman +1
Personalized ultra-fractionated stereotactic adaptive radiotherapy (PULSAR) is a novel treatment that delivers radiation in pulses of protracted intervals. Accurate prediction of g…
Exploring Strategies for Personalized Radiation Therapy: Part III Identifying genetic determinants for Radiation Response with Meta Learning
Hao Peng, Yuanyuan Zhang, Steve Jiang +2
Radiation response in cancer is shaped by complex, patient specific biology, yet current treatment strategies often rely on uniform dose prescriptions without accounting for tumor…
Exploring Strategies for Personalized Radiation Therapy Part I Unlocking Response-Related Tumor Subregions with Class Activation Mapping
Hao Peng, Steve Jiang, Robert Timmerman
Personalized precision radiation therapy requires more than simple classification, it demands the identification of prognostic, spatially informative features and the ability to ad…
Exploring Strategies for Personalized Radiation Therapy Part II Predicting Tumor Drift Patterns with Diffusion Models
Hao Peng, Steve Jiang, Robert Timmerman
Radiation therapy outcomes are decided by two key parameters, dose and timing, whose best values vary substantially across patients. This variability is especially critical in the…
Mathematical Modeling of the Synergetic Effect between Radiotherapy and Immunotherapy
Yixun Xing, Casey Moore, Debabrata Saha +6
Achieving effective synergy between radiotherapy and immunotherapy is critical for optimizing tumor control and treatment outcomes. To explore the underlying mechanisms of this syn…