404 citations · 547 across the 4 of their papers we have counts for
4 papers · 1 filter
The role of packaging sites in efficient and specific virus assembly
J. D. Perlmutter, M. F. Hagan
During the lifecycle of many single-stranded RNA viruses, including many human pathogens, a protein shell called the capsid spontaneously assembles around the viral genome. Underst…
Mechanisms of virus assembly
Jason D Perlmutter, Michael F Hagan
Viruses are nanoscale entities containing a nucleic acid genome encased in a protein shell called a capsid, and in some cases surrounded by a lipid bilayer membrane. This review su…
Pathways for virus assembly around nucleic acids
Jason D Perlmutter, Matthew R Perkett, Michael F Hagan
Understanding the pathways by which viral capsid proteins assemble around their genomes could identify key intermediates as potential drug targets. In this work we use computer sim…
Viral genome structures are optimal for capsid assembly
Jason D. Perlmutter, Cong Qiao, Michael F. Hagan
Understanding how virus capsids assemble around their nucleic acid (NA) genomes could promote efforts to block viral propagation or to reengineer capsids for gene therapy applicati…