3 papers
cs.LG2025
Multiscale guidance of protein structure prediction with heterogeneous cryo-EM data
Rishwanth Raghu, Axel Levy, Gordon Wetzstein +1
Protein structure prediction models are now capable of generating accurate 3D structural hypotheses from sequence alone. However, they routinely fail to capture the conformational…
cs.CV2025
CryoBench: Diverse and challenging datasets for the heterogeneity problem in cryo-EM
Minkyu Jeon, Rishwanth Raghu, Miro Astore +6
Cryo-electron microscopy (cryo-EM) is a powerful technique for determining high-resolution 3D biomolecular structures from imaging data. Its unique ability to capture structural va…
cs.LG2024
Mixture of neural fields for heterogeneous reconstruction in cryo-EM
Axel Levy, Rishwanth Raghu, David Shustin +5
Cryo-electron microscopy (cryo-EM) is an experimental technique for protein structure determination that images an ensemble of macromolecules in near-physiological contexts. While…