3 papers
physics.bio-ph2018
First-passage processes on a filamentous track in a dense traffic: optimizing diffusive search for a target in crowding conditions
Soumendu Ghosh, Bhavya Mishra, Anatoly B. Kolomeisky +1
Several important biological processes are initiated by the binding of a protein to a specific site on the DNA. The strategy adopted by a protein, called transcription factor (TF),…
cond-mat.stat-mech2018
A Biologically Motivated Asymmetric Exclusion Process: interplay of congestion in RNA polymerase traffic and slippage of nascent transcript
Soumendu Ghosh, Annwesha Dutta, Shubhadeep Patra +3
We develope a theoretical framework, based on exclusion process, that is motivated by a biological phenomenon called transcript slippage (TS). In this model a discrete lattice repr…
physics.bio-ph2015
Mixed molecular motor traffic on nucleic acid tracks: models of transcriptional interference and regulation of gene expression
Tripti Bameta, Debashish Chowdhury, Dipanwita Ghanti +1
RNA polymerase (RNAP) is molecular machine that polymerizes a RNA molecule, a linear heteropolymer, using a single stranded DNA (ssDNA) as the corresponding template; the sequence…