8 papers
Dimensionality and confinement reshape competition in cellular renewing active matter
Patrick Zimmer, Philip Bittihn, Yoav G. Pollack
Cellular renewing active matter - assemblies of proliferating and apoptotic cells - underlies tissue homeostasis, morphogenesis, and clonal competition. Previous work in one-dimens…
Orientational lineage memory and mechanical ordering during diffusion-limited growth
Ilias-Marios Sarris, Ramin Golestianian, Philip Bittihn
Growth and shape formation in crowded multicellular assemblies arise from the interplay of chemical gradients, single-cell expansion and mechanical interactions, making it essentia…
Order and shape dependence of mechanical relaxation in proliferating active matter
Jonas Isensee, Lukas Hupe, Philip Bittihn
Collective dynamics in proliferating anisotropic particle systems arise from an interplay between growth, division, and mechanical interactions, often mediated by particle shape. I…
Prediction and control of geometry-induced nematic order in growing multicellular systems
Lukas Hupe, Jonas Isensee, Ramin Golestanian +1
In densely-packed two-dimensional systems of growing cells, such as rod-shaped bacteria, a number of experimental and numerical studies report distinct patterns of nematic orientat…
Phase separation in a mixture of proliferating and motile active matter
Lukas Hupe, Joanna M. Materska, David Zwicker +3
Proliferation and motility are ubiquitous drivers of activity in biological systems. Here, we study a dense binary mixture of motile and proliferating particles with exclusively re…
Motility-induced mixing transition in exponentially growing multicellular spheroids
Torben Sunkel, Lukas Hupe, Philip Bittihn
Growth drives cellular dynamics in dense aggregates including bacterial colonies, developing tissues, and tumors. We investigate the underlying physical principles emerging from th…