6 papers
Mechanistic Modeling of Continuous Lyophilization for Biopharmaceutical Manufacturing
Prakitr Srisuma, Gang Chen, Richard D. Braatz
Lyophilization (aka freeze drying) is a typical process in pharmaceutical manufacturing used for improving the stability of various drug products, including its recent applications…
Highly Efficient Optimal Control for Lyophilization via Simulation of Discrete/Continuous Mixed-index Differential-algebraic Equations
Prakitr Srisuma, Richard D. Braatz
This article presents a highly efficient optimal control algorithm and policies for lyophilization (also known as freeze drying). The optimal solutions and control policies are der…
Simulation-based Approach for Fast Optimal Control of a Stefan Problem with Application to Cell Therapy
Prakitr Srisuma, George Barbastathis, Richard D. Braatz
This article describes a new, efficient way of finding control and state trajectories in optimal control problems by reformulation as a system of differential-algebraic equations (…
Probabilistically Robust Uncertainty Analysis and Optimal Control of Continuous Lyophilization via Polynomial Chaos Theory
Prakitr Srisuma, George Barbastathis, Richard D. Braatz
Lyophilization, aka freeze drying, is a process commonly used to increase the stability of various drug products in biotherapeutics manufacturing, e.g., mRNA vaccines, allowing for…
Real-time Estimation of Bound Water Concentration during Lyophilization with Temperature-based State Observers
Prakitr Srisuma, George Barbastathis, Richard Braatz
Lyophilization (aka freeze drying) has been shown to provide long-term stability for many crucial biotherapeutics, e.g., mRNA vaccines for COVID-19, allowing for higher storage tem…
Mechanistic Modeling and Analysis of Thermal Radiation in Conventional, Microwave-assisted, and Hybrid Freeze Drying for Biopharmaceutical Manufacturing
Prakitr Srisuma, George Barbastathis, Richard D. Braatz
In freeze drying, thermal radiation has a significant effect on the drying process of vials located near the corner and edge of the trays, resulting in non-uniformity of the produc…