239 citations · 412 across the 24 of their papers we have counts for
5 papers · 1 filter
The Linear-Noise Approximation and moment-closure approximations for stochastic chemical kinetics
Abhyudai Singh, Ramon Grima
This is a short review of two common approximations in stochastic chemical and biochemical kinetics. It will appear as Chapter 6 in the book "Quantitative Biology: Theory, Computat…
Effect of gene-expression bursts on stochastic timing of cellular events
Khem Raj Ghusinga, Abhyudai Singh
Gene expression is inherently a noisy process which manifests as cell-to-cell variability in time evolution of proteins. Consequently, events that trigger at critical threshold lev…
A mechanistic first--passage time framework for bacterial cell-division timing
Khem Raj Ghusinga, Cesar A. Vargas-Garcia, Abhyudai Singh
How exponentially growing cells maintain size homeostasis is an important fundamental problem. Recent single-cell studies in prokaryotes have uncovered the adder principle, where c…
Moment Closure Approximations in a Genetic Negative Feedback Circuit
Mohammad Soltani, Cesar Vargas, Niraj Kumar +2
Auto-regulation, a process wherein a protein negatively regulates its own production, is a common motif in gene expression networks. Negative feedback in gene expression plays a cr…
Nonspecific transcription factor binding reduces variability in transcription factor and target protein expression
Mohammad Soltani, Pavol Bokes, Zachary Fox +1
Transcription factors (TFs) interact with a multitude of binding sites on DNA and partner proteins inside cells. We investigate how nonspecific binding/unbinding to such decoy bind…