75 citations · 210 across the 26 of their papers we have counts for
3 papers · 1 filter
Effects of receptor clustering on ligand dissociation: Theory and simulations
Manoj Gopalakrishnan, Kimberly Forsten-Williams, Matthew A. Nugent +1
Receptor-ligand binding is a critical first step in signal transduction and the duration of the interaction can impact signal generation. In mammalian cells, clustering of receptor…
Ligand Rebinding: Self-consistent Mean-field Theory and Numerical Simulations Applied to SPR Studies
Manoj Gopalakrishnan, Kimberly Forsten-Williams, Theressa R. Cassino +3
Rebinding of dissociated ligands from cell surface proteins can confound quantitative measurements of dissociation rates important for characterizing the affinity of binding intera…
Bond percolation of polymers
Manoj Gopalakrishnan, Beate Schmittmann, R. K. P. Zia
We study bond percolation of non-interacting Gaussian polymers of segments on a 2D square lattice of size with reflecting boundaries. Through simulations, we find th…