75 citations · 210 across the 26 of their papers we have counts for
7 papers · 1 filter
Effects of aging in catastrophe on the steady state and dynamics of a microtubule population
V. Jemseena, Manoj Gopalakrishnan
Several independent observations have suggested that catastrophe transition in microtubules is not a first-order process, as is usually assumed. Recent {\it in vitro} observations…
Microtubule catastrophe from protofilament dynamics
Jemseena V., Manoj Gopalakrishnan
The disappearance of the guanosine triphosphate (GTP)-tubulin cap is widely believed to be the forerunner event for the growth-shrinkage transition (`catastrophe') in microtubule f…
Memory, Bias and Correlations in Bidirectional Transport of Molecular Motor-driven Cargoes
Deepak Bhat, Manoj Gopalakrishnan
Molecular motors are specialized proteins which perform active, directed transport of cellular cargoes on cytoskeletal filaments. In many cases, cargo motion powered by motor prote…
Effectiveness of a dynein team in tug-of-war helped by reduced load-sensitivity of detachment: evidence from study of bidirectional endosome transport in Dictyostelium discoideum
Deepak Bhat, Manoj Gopalakrishnan
Bidirectional cargo transport by molecular motors in cells is a complex phenomenon, in which the cargo (usually a vesicle) alternately moves in retrograde and anterograde direction…
A first-passage-time theory for search and capture of chromosomes by microtubules in mitosis
Manoj Gopalakrishnan, Bindu S. Govindan
The mitotic spindle is an important intermediate structure in eukaryotic cell division, in which each of a pair of duplicated chromosomes is attached through microtubules to centro…
Self-consistent theory of reversible ligand binding to a spherical cell
Shivam Ghosh, Manoj Gopalakrishnan, Kimberly Forsten-Williams
In this article, we study the kinetics of reversible ligand binding to receptors on a spherical cell surface using a self-consistent stochastic theory. Binding, dissociation, diffu…
Effects of receptor clustering on ligand dissociation: Theory and simulations
Manoj Gopalakrishnan, Kimberly Forsten-Williams, Matthew A. Nugent +1
Receptor-ligand binding is a critical first step in signal transduction and the duration of the interaction can impact signal generation. In mammalian cells, clustering of receptor…