3 papers
stat.AP2026
Synergy Area with FDR-controlled Evaluation (SAFE) to robustly assess safety profile in clinical trials
Tianyu Zhan, Yabing Mai, Yihua Gu +2
Safety assessment plays a fundamental role in developing a new drug via clinical trials for ethical considerations. Due to complexity, manual review is typically conducted on the t…
stat.AP2019
Teasing out the overall survival benefit with adjustment for treatment switching to other therapies
Yuqing Xu, Meijing Wu, Weili He +2
In oncology clinical trials, characterizing the long-term overall survival (OS) benefit for an experimental drug or treatment regimen (experimental group) is often unobservable if…
math.ST2015
Combining Survival Trials Using Aggregate Data Based on Misspecified Models
Tinghui Yu, Yabing Mai, Sherry Liu +1
The treatment effects of the same therapy observed from multiple clinical trials can often be very different. Yet the patient characteristics accounting for these differences may n…