374 citations · 736 across the 16 of their papers we have counts for
18 papers
Conformational Fluctuations and Phases in Fused in Sarcoma (FUS) Low-Complexity Domain
D. Thirumalai, Abhinaw Kumar, Debayan Chakraborty +2
The well known phenomenon of phase separation in synthetic polymers and proteins has become a major topic in biophysics because it has been invoked as a mechanism of compartment fo…
Finite-size effects and optimal system sizes in simulations of surfactant micelle self-assembly
Jonathan J. Harris, George A. Pantelopulos, John E. Straub
The spontaneous formation of micelles in aqueous solutions is governed by the amphipathic nature of surfactants and is practically interesting due to the regular use of micelles as…
Aerosol-OT surfactant forms stable reverse micelles in aploar solvent in the absence of water
Ryo Urano, George A. Pantelopulos, John E. Straub
Normal micelle aggregates of amphiphilic surfactant in aqueous solvent are formed by a process of entropically driven self-assembly. The self-assembly of reverse micelles from amph…
Propensity to form amyloid fibrils is encoded as excitations in the free energy landscape of monomeric proteins
Pavel I. Zhuravlev, Govardhan Reddy, John E. Straub +1
Protein aggregation, linked to many of diseases, is initiated when monomers access rogue conformations that are poised to form amyloid fibrils. We show, using simulations of src SH…
Membrane-protein interactions hold the key to understanding amyloid formation
John E. Straub, D. Thirumalai
In this perspective we describe the critical role membranes play in modulating the structures of the Amyloid Precursor Proteins to produce the peptides involved in the Alzheimer's…
Entropic Stabilization of Proteins by TMAO
Samuel S. Cho, Govardhan Reddy, John E. Straub +1
To understand the mechanism of trimethylamine N-oxide (TMAO) induced stabilization of folded protein states, we systematically investigated the action of TMAO on several model dipe…