176 citations · 510 across the 8 of their papers we have counts for
5 papers · 1 filter
Increased signaling entropy in cancer requires the scale-free property of protein interaction networks
Andrew E. Teschendorff, Christopher R. S. Banerji, Simone Severini +2
One of the key characteristics of cancer cells is an increased phenotypic plasticity, driven by underlying genetic and epigenetic perturbations. However, at a systems-level it is u…
Signalling Entropy: a novel network-theoretical framework for systems analysis and interpretation of functional omic data
Andrew Teschendorff, Peter Sollich, Reimer Kuehn
A key challenge in systems biology is the elucidation of the underlying principles, or fundamental laws, which determine the cellular phenotype. Understanding how these fundamental…
Cellular network entropy as the energy potential in Waddington's differentiation landscape
Christopher R. S. Banerji, Diego Miranda-Saavedra, Simone Severini +4
Differentiation is a key cellular process in normal tissue development that is significantly altered in cancer. Although molecular signatures characterising pluripotency and multip…
On dynamic network entropy in cancer
James West, Ginestra Bianconi, Simone Severini +1
The cellular phenotype is described by a complex network of molecular interactions. Elucidating network properties that distinguish disease from the healthy cellular state is there…
Increased entropy of signal transduction in the cancer metastasis phenotype
Andrew Teschendorff, Simone Severini
Studies into the statistical properties of biological networks have led to important biological insights, such as the presence of hubs and hierarchical modularity. There is also a…