6 citations · 12 across the 14 of their papers we have counts for
4 papers · 1 filter
Optimal evolutionary control for artificial selection on molecular phenotypes
Armita Nourmohammad, Ceyhun Eksin
Controlling an evolving population is an important task in modern molecular genetics, including directed evolution for improving the activity of molecules and enzymes, in breeding…
Information-geometric optimization with natural selection
Jakub Otwinowski, Colin LaMont
Evolutionary algorithms, inspired by natural evolution, aim to optimize difficult objective functions without computing derivatives. Here we detail the relationship between populat…
On generative models of T-cell receptor sequences
Giulio Isacchini, Zachary Sethna, Yuval Elhanati +3
T-cell receptors (TCR) are key proteins of the adaptive immune system, generated randomly in each individual, whose diversity underlies our ability to recognize infections and mali…
The size of the immune repertoire of bacteria
Serena Bradde, Armita Nourmohammad, Sidhartha Goyal +1
Some bacteria and archaea possess an immune system, based on the CRISPR-Cas mechanism, that confers adaptive immunity against phage. In such species, individual bacteria maintain a…