203 citations · 312 across the 5 of their papers we have counts for
5 papers
A Reaction-Diffusion Model of the Cadherin-Catenin System: A Possible Mechanism for Contact Inhibition and Implications for Tumorigenesis
Markus Basan, Timon Idema, Martin Lenz +2
Contact inhibition is the process by which cells switch from a motile growing state to a passive and stabilized state upon touching their neighbors. When two cells touch, an adhesi…
Morphological instabilities of stratified epithelia: a mechanical instability in tumour formation
Thomas Risler, Markus Basan
Interfaces between stratified epithelia and their supporting stromas commonly exhibit irregular shapes. Undulations are particularly pronounced in dysplastic tissues and typically…
Stress Clamp Experiments on Multicellular Tumor Spheroids
Fabien Montel, Morgan Delarue, Jens Elgeti +8
The precise role of the microenvironment on tumor growth is poorly understood. Whereas the tumor is in constant competition with the surrounding tissue, little is known about the m…
Undulation Instability of Epithelial Tissues
Markus Basan, Jean-Francois Joanny, Jacques Prost +1
Treating the epithelium as an incompressible fluid adjacent to a viscoelastic stroma, we find a novel hydrodynamic instability that leads to the formation of protrusions of the epi…
Homeostatic competition drives tumor growth and metastasis nucleation
Markus Basan, Thomas Risler, Jean-Francois Joanny +2
We propose a mechanism for tumor growth emphasizing the role of homeostatic regulation and tissue stability. We show that competition between surface and bulk effects leads to the…