3 papers
q-bio.QM2025
Understanding temperature tuning in energy-based models
Peter W Fields, Vudtiwat Ngampruetikorn, David J Schwab +1
Generative models of complex systems often require post-hoc parameter adjustments to produce useful outputs. For example, energy-based models for protein design are sampled at an a…
q-bio.QM2025
Optimization and variability can coexist
Marianne Bauer, William Bialek, Chase Goddard +6
Many biological systems perform close to their physical limits, but promoting this optimality to a general principle seems to require implausibly fine tuning of parameters. Using e…
q-bio.NC2024
Probabilistic models, compressible interactions, and neural coding
Luisa Ramirez, William Bialek, Stephanie E. Palmer +1
In physics we often use very simple models to describe systems with many degrees of freedom, but it is not clear why or how this success can be transferred to the more complex biol…