ATP-Independent Entropy-Driven dsRNA Unwinding by DDX3X Revealed by Coarse-Grained Simulations and Deep Learning

Kang Wang, Chun-Lai Ren, Yu-Qiang Ma

DEAD-box RNA helicases (DDXs) are traditionally known as ATP-dependent motors that unwind double-stranded RNA (dsRNA). Recent experiments, however, show that some DDXs promote dsRN…