119 citations · 499 across the 21 of their papers we have counts for
5 papers · 1 filter
Simulating Brain Tumor Heterogeneity with a Multiscale Agent-Based Model: Linking Molecular Signatures, Phenotypes and Expansion Rate
Le Zhang, Costas G. Strouthos, Zhihui Wang +1
We have extended our previously developed 3D multi-scale agent-based brain tumor model to simulate cancer heterogeneity and to analyze its impact across the scales of interest. Whi…
Cancer Dissemination: A Consequence of limited Carrying Capacity?
Thomas S. Deisboeck, Zhihui Wang
Assuming that there is feedback between an expanding cancer system and its organ-typical microenvironment, we argue here that such local tumor growth is guided by co-existence rath…
Directionality of glioblastoma invasion in a 3d in vitro experiment
A M Stein, D A Vader, T S Deisboeck +3
Glioblastoma is the most malignant form of brain cancer. It is extremely invasive; the mechanisms that govern invasion are not well understood. To better understand the process of…
Development of a Three-Dimensional Multiscale Agent-Based Tumor Model: Simulating Gene-Protein Interaction Profiles, Cell Phenotypes & Multicellular Patterns in Brain Cancer
Le Zhang, Chaitanya A. Athale, Thomas S. Deisboeck
Experimental evidence suggests that epidermal growth factor receptor (EGFR)-mediated activation of the signaling protein phospholipase C gamma plays a critical role in a cancer cel…
Does Cancer Growth Depend on Surface Extension?
Thomas S. Deisboeck, Caterina Guiot, Pier Paolo Delsanto +1
We argue that volumetric growth dynamics of a solid cancer depend on the tumor system's overall surface extension. While this at first may seem evident, to our knowledge, so far no…