105 citations · 113 across the 10 of their papers we have counts for
5 papers · 1 filter
Cancer Cell Motility: Optimizing Spatial Search Strategies
L. Leon Chen, Le Zhang, Jeongah Yoon +1
Aberrantly regulated cell motility is a hallmark of cancer cells. A hybrid agent-based model has been developed to investigate the synergistic and antagonistic cell motility-impact…
Multi-Scale, Multi-Resolution Brain Cancer Modeling
Le Zhang, L. Leon Chen, Thomas S. Deisboeck
In advancing discrete-based computational cancer models towards clinical applications, one faces the dilemma of how to deal with an ever growing amount of biomedical data that ough…
Directionality of glioblastoma invasion in a 3d in vitro experiment
A M Stein, D A Vader, T S Deisboeck +3
Glioblastoma is the most malignant form of brain cancer. It is extremely invasive; the mechanisms that govern invasion are not well understood. To better understand the process of…
The Effects of EGF-Receptor Density on Multiscale Tumor Growth Patterns
Chaitanya A. Athale, Thomas S. Deisboeck
We studied the effects of epidermal growth factor receptor (EGFR) density on tumor growth dynamics, both on the sub- and the multi-cellular level using our previously developed mod…
Simulating the Impact of a Molecular 'Decision-Process' on Cellular Phenotype and Multicellular Patterns in Brain Tumors
Chaitanya Athale, Yuri Mansury, Thomas S. Deisboeck
Experimental evidence indicates that human brain cancer cells proliferate or migrate, yet do not display both phenotypes at the same time. Here, we present a novel computational mo…