3 papers
q-bio.GN2015
BACOM2: a Java tool for detecting normal cell contamination of copy number in heterogeneous tumor
Yi Fu, Jun Ruan, Guoqiang Yu +6
We develop a cross-platform open-source Java application (BACOM2) with graphic user interface (GUI), and users also can use a XML file to set the parameters of algorithm model, fil…
q-bio.QM2014
A Statistical Approach to Identifying Significant Transgenerational Methylation Changes
Ye Tian, Yi Fu, Guoqiang Yu +2
Epigenetic aberrations have profound effects on phenotypic output. Genome wide methylation alterations are inheritable to pass down the aberrations through multiple generations. We…
q-bio.GN2013
BACOM 2.0 facilitates absolute normalization and quantification of somatic copy number alterations in heterogeneous tumor
Yi Fu, Guoqiang Yu, Douglas A. Levine +5
BACOM is a statistically principled and unsupervised method that detects copy number deletion types (homozygous versus heterozygous), estimates normal cell fraction, and recovers c…