20 citations · 51 across the 13 of their papers we have counts for
5 papers · 1 filter
Promotion/Inhibition Effects in Networks: A Model with Negative Probabilities
Anqi Dong, Tryphon T. Georgiou, Allen Tannenbaum
Biological networks often encapsulate promotion/inhibition as signed edge-weights of a graph. Nodes may correspond to genes assigned expression levels (mass) of respective proteins…
Comparing Three Notions of Discrete Ricci Curvature on Biological Networks
Maryam Pouryahya, James Mathews, Allen Tannenbaum
In the present work, we study the properties of biological networks by applying analogous notions of fundamental concepts in Riemannian geometry and optimal mass transport to discr…
A Quantitative Analysis of Localized Robustness of MYCN in Neuroblastoma
Romeil Sandhu, Sarah Tannenbaum, Daniel Diolaiti +3
The amplification of the gene MYCN (V-myc myelocytomatosis viral-valeted oncogene, neuroblastoma derived) has been a well-documented indicator for poor prognosis in neuroblastoma,…
An Analytical Approach for Insulin-like Growth Factor Receptor 1 and Mammalian Target of Rapamycin Blockades in Ewing Sarcoma
Romeil Sandhu, Salah-Eddine Lamhamedi-Cherradi, Sarah Tannenbaum +2
We present preliminary results that quantify network robustness and fragility of Ewing sarcoma (ES), a rare pediatric bone cancer that often exhibits de novo or acquired drug resis…
Graph Curvature and the Robustness of Cancer Networks
Allen Tannenbaum, Chris Sander, Liangjia Zhu +5
The importance of studying properties of networks is manifest in diverse fields ranging from biology, engineering, physics, chemistry, neuroscience, and medicine. The functionality…