2 papers
stat.ME2023
Methods for non-proportional hazards in clinical trials: A systematic review
Maximilian Bardo, Cynthia Huber, Norbert Benda +13
For the analysis of time-to-event data, frequently used methods such as the log-rank test or the Cox proportional hazards model are based on the proportional hazards assumption, wh…
q-bio.QM2015
PopED lite: an optimal design software for preclinical pharmacokinetic and pharmacodynamic studies
Yasunori Aoki, Monika Sundqvist, Andrew C. Hooker +1
Optimal experimental design approaches are seldom used in pre-clinical drug discovery. Main reasons for this lack of use are that available software tools require relatively high i…