2 papers
math.NA2018
Cluster Gauss-Newton method for finding multiple approximate minimisers of nonlinear least squares problems with applications to parameter estimation of pharmacokinetic models
Yasunori Aoki, Ken Hayami, Kota Toshimoto +1
Parameter estimation problems of mathematical models can often be formulated as nonlinear least squares problems. Typically these problems are solved numerically using iterative me…
q-bio.QM2015
PopED lite: an optimal design software for preclinical pharmacokinetic and pharmacodynamic studies
Yasunori Aoki, Monika Sundqvist, Andrew C. Hooker +1
Optimal experimental design approaches are seldom used in pre-clinical drug discovery. Main reasons for this lack of use are that available software tools require relatively high i…