activity
20142026
most citedSingle-particle cryo-electron microscopy: Mathematical theory, computational challenges, and opportunities

148 citations · 567 across the 75 of their papers we have counts for

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Showing 2026Show all

10 papers · 1 filter

math.NA2026

Provable Method of Moments for Cryo-EM

Amnon Balanov, Tamir Bendory, Dan Edidin +3

We study the recovery of a three-dimensional volume in single-particle cryo-electron microscopy (cryo-EM) from noisy tomographic projections acquired at unknown viewing rotations,…

eess.SP2026

A Geometric Analysis of Initialization Bias in Spherical -means in the Weak Signal Regime

Amnon Balanov, Tamir Bendory

We study initialization bias in spherical -means for weakly informative directional mixtures. We model the observations by a -component von Mises-Fisher mixture with a small…

math.ST2026

The generalized method of moments is (almost) statistically efficient in low-SNR Gaussian latent-variable models

Amnon Balanov, Tamir Bendory, Dan Edidin

We study estimation in the low signal-to-noise ratio (SNR) regime for a broad class of Gaussian latent-variable models, including Gaussian mixtures and orbit recovery problems. We…

eess.SP2026

Projected multi-reference alignment

Amnon Balanov, Josh Katz, Tamir Bendory +1

Motivated by structural biology applications, we study the projected multi-reference alignment (MRA) model, in which an unknown signal is observed through noisy samples, each gener…

eess.SP2026

The interplay of signal-to-noise ratio and variance misspecification in Gaussian mixtures

Vladimir Serov, Amnon Balanov, Tamir Bendory

We study estimation and clustering in Gaussian mixture models under variance misspecification. Observations are generated with true variance , while the component means are es…

eess.SP2026

Group-invariant moments under tomographic projections

Amnon Balanov, Tamir Bendory, Dan Edidin

Let be an unknown object, and suppose the observations are tomographic projections of randomly rotated copies of of the form , wh…

math.ST2026

Inhomogeneous Submatrix Detection

Mor Oren-Loberman, Dvir Jerbi, Tamir Bendory +1

In this paper, we study the problem of detecting multiple hidden submatrices in a large Gaussian random matrix when the planted signal is inhomogeneous across entries. Under the nu…

eess.SP2026

Provable orbit recovery over SO(3) from the non-uniform second moment

Tamir Bendory, Dan Edidin, Josh Katz +2

We study the recovery of an unknown three-dimensional band-limited signal from multiple noisy observations that are randomly rotated by latent elements of SO(3), where the rotation…

stat.ML2026

The Catastrophic Failure of The k-Means Algorithm in High Dimensions, and How Hartigan's Algorithm Avoids It

Roy R. Lederman, David Silva-Sánchez, Ziling Chen +3

Lloyd's k-means algorithm is one of the most widely used clustering methods. We prove that in high-dimensional, high-noise settings, the algorithm exhibits catastrophic failure: wi…

eess.SP2026

A Fast Approximate Maximum Likelihood Estimator for Low SNR Multi-Reference Alignment

Shay Kreymer, Amnon Balanov, Tamir Bendory

Motivated by single-particle cryo-electron microscopy, multi-reference alignment (MRA) models the task of recovering an unknown signal from multiple noisy observations corrupted by…