7 papers
Accurate de novo sequencing of the modified proteome with OmniNovo
Yuhan Chen, Shang Qu, Zhiqiang Gao +13
Post-translational modifications (PTMs) serve as a dynamic chemical language regulating protein function, yet current proteomic methods remain blind to a vast portion of the modifi…
A Survey of Reinforcement Learning for Large Reasoning Models
Kaiyan Zhang, Yuxin Zuo, Bingxiang He +36
In this paper, we survey recent advances in Reinforcement Learning (RL) for reasoning with Large Language Models (LLMs). RL has achieved remarkable success in advancing the frontie…
TTRL: Test-Time Reinforcement Learning
Yuxin Zuo, Kaiyan Zhang, Li Sheng +13
This paper investigates Reinforcement Learning (RL) on data without explicit labels for reasoning tasks in Large Language Models (LLMs). The core challenge of the problem is reward…
Automating Exploratory Multiomics Research via Language Models
Shang Qu, Ning Ding, Linhai Xie +13
This paper introduces PROTEUS, a fully automated system that produces data-driven hypotheses from raw data files. We apply PROTEUS to clinical proteogenomics, a field where effecti…
MedXpertQA: Benchmarking Expert-Level Medical Reasoning and Understanding
Yuxin Zuo, Shang Qu, Yifei Li +6
We introduce MedXpertQA, a highly challenging and comprehensive benchmark to evaluate expert-level medical knowledge and advanced reasoning. MedXpertQA includes 4,460 questions spa…
Technologies on Effectiveness and Efficiency: A Survey of State Spaces Models
Xingtai Lv, Youbang Sun, Kaiyan Zhang +8
State Space Models (SSMs) have emerged as a promising alternative to the popular transformer-based models and have been increasingly gaining attention. Compared to transformers, SS…