2 papers
q-bio.BM2015
New class of compounds - variators - are reprogramming substrate specificity of H4K12Ac, H4K16Ac and H4K20Ac epigenetic marks reading bromodomain of BPTF protein
Oleksandr Ya Yakovenko, Sreeja Leelakumari, Ganna Vashchenko +2
Previously reported [http://arxiv.org/abs/1506.06433] reprogramming of substrate specificity of H3K4Me3 epigenetic marks reading PHD domain of BPTF protein illustrates therapeutic…
q-bio.BM2015
New class of compounds - variators - are reprogramming substrate specificity of H3K4me3 epigenetic marks reading PHD domain of BPTF protein
Oleksandr Ya Yakovenko, Sreeja Leelakumari, Ganna Vashchenko +3
In lymphoma, mutations in genes of histone modifying proteins are frequently observed. Notably, somatic mutations in the activatory histone modification writing protein MLL2 and th…