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Hierarchy and Feedback in the Evolution of the E. coli Transcription Network
M. Cosentino Lagomarsino, P. Jona, B. Bassetti +1
The E.coli transcription network has an essentially feedforward structure, with, however, abundant feedback at the level of self-regulations. Here, we investigate how these propert…
Randomization and Feedback Properties of Directed Graphs Inspired by Gene Networks
M. Cosentino Lagomarsino, B. Bassetti, P. Jona
Having in mind the large-scale analysis of gene regulatory networks, we review a graph decimation algorithm, called "leaf-removal", which can be used to evaluate the feedback in a…
The large-scale logico-chemical structure of a transcriptional regulation network
M. Cosentino Lagomarsino, P. Jona, B. Bassetti
Identity, response to external stimuli, and spatial architecture of a living system are central topics of molecular biology. Presently, they are largely seen as a result of the int…
The Logic Backbone of a Transcription Network
M. Cosentino Lagomarsino, P. Jona, B. Bassetti
A great part of the effort in the study of coarse grained models of transcription networks is directed to the analysis of their dynamical features. In this letter, we consider the…