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q-bio.PE2026
Epistatic strength, modularity, and locus heterogeneity shape the number of local optima in fitness landscapes
Mahan Ghafari, Alejandro Castro Cabrera, Alejandro Lage-Castellanos +3
Fitness landscapes provide a quantitative framework for understanding how natural selection shapes evolutionary trajectories. A central feature of these landscapes is their number…
q-bio.PE2026
Simple sign epistasis and evolutionary detours in fitness landscapes
Paolo Ribeca, Alejandro Castro, Alejandro Lage-Castellanos +8
In epistatic fitness landscapes, the fitness effect of a mutation depends on the genetic background and may even switch between deleterious and beneficial depending on the presence…