4 papers
Effects of cell-cell communication on bacterial chemotaxis
Soutick Saha, Sean Fancher, Andrew Mugler
Bacteria track chemical gradients using a biased random walk, a process called chemotaxis. Experiments suggest that bacteria also communicate during this process. Using a mathemati…
Exosome-mediated chemotaxis optimizes leader-follower cell migration
Louis González, Andrew Mugler
Cells frequently employ extracellular vesicles, or exosomes, to signal across long distances and coordinate collective actions. Exosomes diffuse slowly, can be actively degraded, a…
Quantifying cellular autonomy in multi-cue environments
Louis Gonzalez, Hogyeong Gwak, Bumsoo Han +1
A cell routinely responds to one of many competing environmental cues. A fundamental question is whether the cell follows the cue prioritized by its internal signaling network or t…
Near-critical gene expression in embryonic boundary precision
Michael Vennettilli, Krishna P. Ramachandran, Andrew Mugler
Embryonic development relies on the formation of sharp, precise gene expression boundaries. In the fruit fly Drosophila melanogaster, boundary formation has been proposed to occur…