13 citations · 30 across the 30 of their papers we have counts for
32 papers
Thermodynamic optimization of thermal landscapes and energy barriers in a Brownian heat engine
Mesfin Taye
Spatial temperature fields in Brownian heat engines are commonly prescribed \emph{a priori}, and the resulting transport and thermodynamic properties are then calculated. Here we f…
Exact chemo--thermal Metropolis Brownian engine: chemical leverage, temperature-neutral stall, power optimization, and multicyclic dissipation
Mesfin Taye
We develop an exactly solvable chemo--thermal extension of the three-state Metropolis Brownian heat engine. The particle moves through the periodic energy sequence $0\to E\to 2E\to…
Stochastic First-Passage Theory of HIV Viral Rebound Following Latent Reservoir Reactivation
Mesfin Asfaw Taye
In our earlier work, we modeled the stochastic initiation of HIV rebound by treating latent-cell reactivation as a Poisson-driven process during antiretroviral-therapy (ART) washou…
Relativistic PBTE:Biological Proper Time Along the Worldline
Mesfin Asfaw Taye
Biological aging is conventionally indexed by chronological time, yet every organism is a physical system tracing a worldline through spacetime, so the time available to its metabo…
Biological Time, Evolutionary Optimization, and Gauge Coherence: A Thermodynamic Synthesis of the Principle of Biological Time Equivalence
Mesfin Asfaw Taye
Biological theory usually treats time as an external chronological variable against which growth, aging, and ecological change are parametrized. Yet living systems also generate an…
A Nonequilibrium Internal-Time Model of Aging: Entropy-Normalized Biological Proper Time and Repair Bifurcations
Mesfin Taye
Chronological age is an incomplete coordinate for aging. Individuals and species sharing the same calendar time can differ substantially in physiological reserve, molecular damage,…
Biological proper time and entropy-cost invariance in cardiac and respiratory lifespan scaling
Mesfin Taye
Warm-blooded vertebrates accumulate approximately conserved numbers of physiological cycles over a natural lifetime: of order heartbeats and -- breaths. T…
Neural Investment as an Entropy-Budget Strategy: A Thermodynamic Derivation of Primate Longevity from the Principle of Biological Time Equivalence
Mesfin Taye
Primates exhibit a robust deviation from canonical allometric scaling: at fixed body mass, their lifespans exceed those of non-primate mammals by factors of two to three. A rhesus…
The Lifetime Cardiac-Cycle Invariant in Endothermic Vertebrates: A 230-Species Comparative Dataset, Statistical Validation, and Explicit Falsifiability Criteria
Mesfin Taye
A pygmy shrew (\textit{Suncus etruscus}, \,g) sustains a resting heart rate near \,beats\,min and dies within two years; an African elephant (${\approx}…
Thermodynamic Parametrisation of the Vertebrate Lifetime Cycle Invariant: Biological Proper Time, Allometric Mass-Cancellation, and Clade-Specific Predictions
Mesfin Taye
Warm-blooded vertebrates accumulate approximately $\Nstar \approx 10^9$ cardiac cycles over a natural lifetime, a striking empirical regularity first quantified by Lindstedt and Ca…
Biological Time Equivalence in Vertebrates: Thermodynamic Framework, Comparative Tests, and Clade-Specific Deviations
Mesfin Taye
The product of resting heart rate and maximum lifespan is approximately constant across adult warm-blooded vertebrates, cardiac cycles, a regularity…
Curzon Ahlborn Type Efficiency in a Brownian Heat Engine with Exponential Temperature Profile
Mesfin Asfaw Taye
We investigate a Brownian heat engine wherein a particle moves through a periodic ratchet potential under an exponentially decreasing temperature profile, a spatial configuration t…
Noise-Activated Dopant Dynamics in Two-Dimensional Thermal Landscapes with Localized Cold Spots
Mesfin Taye, Yoseph Abebe, Tibebe Birhanu +2
Controlling dopant transport with high spatial precision is crucial for improving the semiconductor functionality, reliability, and scalability. Although prior models of noise-assi…
A Unified Nonequilibrium Framework: Thermodynamic Distance, Dissipation, and Stationary Laws via Effective State Count, Variational Stationarity, and Thermodynamic Bounds
Mesfin Taye
We propose a variational framework for nonequilibrium thermodynamics built around the effective number of accessible state, a multiplicative count that ranges from for a uniform di…
Thermodynamic Irreversibility in Underdamped Brownian Motion with Spatial Temperature Gradients
Mesfin Taye
We analyze underdamped Brownian motion in non-isothermal media with quadratic, linear, and piecewise-constant temperature profiles. Exact identities for entropy production and entr…
A Universal Thermodynamic Inequality: Scaling Relations Between Current, Activity, and Entropy Production
Mesfin Taye
We derive a universal thermodynamic bound constraining directional transport in both discrete and continuous nonequilibrium systems. For continuous-time Markov jump processes and o…
Entropy Production and Thermodynamic Dynamics in Active and Passive Brownian Systems Driven by Time Dependent Forces and Temperatures
Mesfin Taye
In this work, we examine the impact of time-varying temperature and force on the thermodynamic features of active Brownian motor that moves with velocity against the force as well…
Thermodynamic Features of a Heat Engine Coupled with Exponentially Decreasing Temperature Across the Reaction Coordinate, as well as Perspectives on Nonequilibrium Thermodynamics
Mesfin Taye
In this study, we advance the understanding of non-equilibrium systems by deriving thermodynamic relations for a heat engine operating under an exponentially decreasing temperature…
Drug Washout and Viral Rebound: Modeling HIV Reactivation Under ART Discontinuation
Mesfin Taye
Due to the persistence of latently infected CD4 T cells, achieving a functional cure for HIV-1 remains a significant challenge since the viruses are able to evade immune cleara…
Dynamics of blood cells during a routine laboratory examination
Mesfin Taye
Centrifugation is a commonly performed laboratory procedure that helps to separate blood cells such as , , and platelets from plasma or serum. Although centrifugation i…
Exact time-dependent analytical solutions for entropy production rate for a system that operates in a heat bath where its temperature varies linearly in space
Mesfin Taye
The nonequilibrium thermodynamics feature of a Brownian motor is investigated by obtaining exact time-dependent solutions. This in turn enables us to investigate not only the long…
Effect of viscous friction on entropy, entropy production and entropy extraction rates in underdamped and overdamped media
Mesfin Asfaw Taye
Considering viscous friction that varies spatially and temporally, the general expressions for entropy production, free energy, and entropy extraction rates are derived to a Browni…
Entropy production and entropy extraction rates for a Brownian particle that walks in underdamped medium
Mesfin Asfaw Taye
The expressions for entropy production, free energy, and entropy extraction rates are derived for a Brownian particle that walks in an underdamped medium. Our analysis indicates th…
The efficacy of antiviral drug, HIV viral load and the immune response
Stephanie Yunfei Zhang, Mesfin Asfaw Taye
Developing antiviral drugs is an exigent task since viruses mutate to overcome the effect of antiviral drugs. As a result, the efficacy of most antiviral drugs is short-lived. To i…