4 papers
Experimental methods to control pinned and coupled actomyosin contraction events
James Clarke, Hyunjae Lee, Kyla Wong +4
Actin and myosin drive many instances of force generation, deformation, and shape change in cells, tissues, and organisms. In particular, cytoskeletal actomyosin is remarkable in i…
Control across scales: signals, information, and adaptive biological mechanical function
James Clarke, Jake McGrath, Colin Johnson +1
Biological systems perform an astonishing array of dynamical processes -- including development and repair, regulation, behavior and motor control, sensing and signaling, and adapt…
Optimal Control in Soft and Active Matter
José Alvarado, Erin Teich, David Sivak +1
Soft and active condensed matter represent a class of fascinating materials that we encounter in our everyday lives -- and constitute life itself. Control signals interact with the…
Microscale velocity-dependent unbinding generates a macroscale performance-efficiency tradeoff in actomyosin systems
Jake McGrath, Brian Kent, Colin Johnson +1
Myosin motors are fundamental biological actuators, powering diverse mechanical tasks in eukaryotic cells via ATP hydrolysis. Recent work revealed that myosin's velocity-dependent…