Linking a genetic defect in migraine to spreading depression in a computational model

Markus A. Dahlem, Julia Schumacher, Niklas Hübel

Familial hemiplegic migraine (FHM) is a rare subtype of migraine with aura. A mutation causing FHM type 3 (FHM3) has been identified in SCN1A encoding the Nav1.1 Na${}^{+}$ channel. Th…