6 papers
Quantifying the Emergence of Selection Prior to Biological Evolution
Michael Jirasek, Abhishek Sharma, Mary Wong +2
Selection is central to biological evolution, yet there has been no general experimental framework for quantifying selection in chemical systems before life. Here we demonstrate th…
Exploring molecular assembly as a biosignature using mass spectrometry and machine learning
Lindsay A. Rutter, Abhishek Sharma, Ian Seet +3
Molecular assembly offers a promising path to detect life beyond Earth, while minimizing assumptions based on terrestrial life. As mass spectrometers will be central to upcoming So…
Chemputer and Chemputation -- A Universal Chemical Compound Synthesis Machine
Leroy Cronin, Sebastian Pagel, Abhishek Sharma
Chemputation reframes synthesis as the programmable execution of reaction code on a universally re-configurable hardware graph. Here we prove that a chemputer equipped with a finit…
Quantifying the Complexity of Materials with Assembly Theory
Keith Y Patarroyo, Abhishek Sharma, Ian Seet +3
Quantifying the evolution and complexity of materials is of importance in many areas of science and engineering, where a central open challenge is developing experimental complexit…
Mapping Evolution of Molecules Across Biochemistry with Assembly Theory
Sebastian Pagel, Abhishek Sharma, Leroy Cronin
Evolution is often understood through genetic mutations driving changes in an organism's fitness, but there is potential to extend this understanding beyond the genetic code. We pr…
AI-Driven Robotic Crystal Explorer for Rapid Polymorph Identification
Edward C Lee, Daniel Salley, Abhishek Sharma +1
Crystallisation is an important phenomenon which facilitates the purification as well as structural and bulk phase material characterisation using crystallographic methods. However…