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Kinetic theory of Hyaluronan cleavage by Bovine Testicular Hyaluronidase in Standard and Crowded Environments
Reine Nehmé, Rouba Nasreddine, Lucija Orlic +3
Details of the kinetic pathways governing enzymatic cleavage of hyaluronic acid (HA) by hyaluronidase are still widely uncharted. Capillary electrophoresis-based…
Tracer diffusion in crowded solutions of sticky polymers
T. P. O. Nogueira, H. O. Frota, Francesco Piazza +1
Macromolecular diffusion in strongly confined geometries and crowded environments is still to a large extent an open subject in soft matter physics and biology. In this paper, we e…
Mesoscale computational protocols for the design of highly cooperative bivalent macromolecules
Suman Saurabh, Francesco Piazza
The last decade has witnessed a swiftly increasing interest in the design and production of novel multivalent molecules as powerful alternatives for conventional antibodies in the…
Diffusion to capture and the concept of diffusive interactions
Marta Galanti, Duccio Fanelli, Sergey D. Traytak +1
Diffusion to capture is an ubiquitous phenomenon in many fields in biology and physical chemistry, with implications as diverse as ligand-receptor binding on eukaryotic and bacteri…
Reaction rate of a composite core-shell nanoreactor with multiple, spatially distributed embedded nano-catalysts
Marta Galanti, Duccio Fanelli, Stefano Angioletti-Uberti +3
We present a detailed theory for the total reaction rate constant of a composite core-shell nanoreactor, consisting of a central solid core surrounded by a hydrogel layer of variab…
On the origin of the Boson peak in globular proteins
Stefano Ciliberti, Paolo De Los Rios, Francesco Piazza
We study the Boson Peak phenomenology experimentally observed in globular proteins by means of elastic network models. These models are suitable for an analytic treatment in the fr…
The Glass-like Structure of Globular Proteins and the Boson Peak
Stefano Ciliberti, Paolo De Los Rios, Francesco Piazza
Vibrational spectra of proteins and topologically disordered solids display a common anomaly at low frequencies, known as Boson peak. We show that such feature in globular proteins…