4 papers
Epigenetic state encodes locus-specific chromatin mechanics
Guang Shi, D. Thirumalai
Chromatin is repeatedly deformed in vivo during transcription, nuclear remodeling, and confined migration - yet how mechanical response varies from locus to locus, and how it relat…
Static Three-Dimensional Structures Determine Fast Dynamics Between Distal Loci Pairs in Interphase Chromosomes
Guang Shi, Sucheol Shin, D. Thirumalai
Live-cell imaging experiments have shown that the distal dynamics between enhancers and promoters are unexpectedly rapid and incompatible with standard polymer models. The discorda…
Minimal Models for RNA Simulations
D. Thirumalai, Naoto Hori, Hung T. Nguyen
The increasing importance of RNA as a prime player in biology can hardly be overstated. Problems in RNA, such as folding and RNA-RNA interactions that drive phase separation, requi…
Organization and Dynamics of Chromosomes
D. Thirumalai, Guang Shi, Sucheol Shin +1
How long threadlike eukaryotic chromosomes fit tidily in the small volume of the nucleus without significant entanglement is just beginning to be understood, thanks to major advanc…