33 citations · 104 across the 13 of their papers we have counts for
5 papers · 1 filter
Self-organization of signal transduction
Gabriele Scheler
We propose a model of parameter learning for signal transduction, where the objective function is defined by signal transmission efficiency. We apply this to learn kinetic rates as…
Transfer Functions for Protein Signal Transduction: Application to a Model of Striatal Neural Plasticity
Gabriele Scheler
We present a novel formulation for biochemical reaction networks in the context of signal transduction. The model consists of input-output transfer functions, which are derived fro…
Dynamic re-wiring of protein interaction: The case of transactivation
Gabriele Scheler
We are looking at local protein interaction networks from the perspective of directed, labeled graphs with quantitative values for monotonic changes in concentrations. These system…
Extracellular-to-intracellular signal transfer via G-proteins
Gabriele Scheler
We look at the problem of signal transduction by extracellular agonist binding to a receptor protein at the membrane (sensor) via binding of G-proteins (effectors) to a highly inte…
Regulation of Neuromodulator Receptor Efficacy - Implications for Whole-Neuron and Synaptic Plasticity
Gabriele Scheler
Membrane receptors for neuromodulators (NM) are highly regulated in their distribution and efficacy - a phenomenon which influences the individual cell's response to central signal…