5 papers
Photon Absorption Remote Sensing Virtual Histopathology: A Preliminary Exploration of Diagnostic Equivalence to Gold-Standard H&E Staining in Skin Cancer Excisional Biopsies
Benjamin R. Ecclestone, James E. D. Tweel, Marie Abi Daoud +7
Photon Absorption Remote Sensing (PARS) enables label-free imaging of subcellular morphology by observing biomolecule specific absorption interactions. Coupled with deep-learning,…
Label-Free Whole Slide Virtual Multi-Staining Using Dual-Excitation Photon Absorption Remote Sensing Microscopy
James E. D. Tweel, Benjamin R. Ecclestone, James A. Tummon Simmons +1
Histochemical staining is essential for visualizing tissue architecture and cellular morphology but is destructive and limited by the availability of tissue for multiple stains. Vi…
Pathology-Guided Virtual Staining Metric for Evaluation and Training
Qiankai Wang, James E. D. Tweel, Parsin Haji Reza +1
Virtual staining has emerged as a powerful alternative to traditional histopathological staining techniques, enabling rapid, reagent-free image transformations. However, existing e…
Photon Absorption Remote Sensing (PARS): Comprehensive Absorption Imaging Enabling Label-Free Biomolecule Characterization and Mapping
Benjamin R. Ecclestone, James A. Tummon Simmons, James E. D. Tweel +2
Label-free optical absorption microscopy techniques continue to evolve as promising tools for label-free histopathological imaging of cells and tissues. However, critical challenge…
Investigation of Non-Radiative Relaxation Dynamics Under Pulsed Excitation Using Photon Absorption Remote Sensing: A Proof-of-Principle Study in Mechanical Sensing
Channprit Kaur, Aria Hajiahmadi, Benjamin R. Ecclestone +3
The mechanical properties of micro-scale bio-entities are fundamental for understanding their functions and pathological states. However, current methods for assessing elastic prop…