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clinical trials 1covariance structure 1longitudinal data 1mixed models 1model convergence 1

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1 paper

stat.ME2026

Optimizing Efficiency and Convergence in MMRM: Practical Considerations for Longitudinal Data Analysis

Dylan Clarke, Jeremiah Jones, Yongming Qu

The paper studies how to improve convergence and efficiency of mixed models for repeated measures (MMRM) in longitudinal clinical trial data, recommending specific covariance struc…