3 papers
q-bio.TO2026
Adaptive therapy under parametric, structural, and measurement uncertainty
Alexander P Browning, Rebecca M Crossley, Ryan J Murphy +2
Adaptive therapy has emerged as a promising treatment strategy that exploits within-tumour competition to delay disease progression. Implementation, however, typically relies on in…
stat.ME2025
A nonparametric approach to practical identifiability of nonlinear mixed effects models
Tyler Cassidy, Stuart T. Johnston, Michael Plank +4
Mathematical modelling is a widely used approach to understand and interpret clinical trial data. This modelling typically involves fitting mechanistic mathematical models to data…
stat.ME2025
A cautionary tale of model misspecification and identifiability
Alexander P Browning, Jennifer A Flegg, Ryan J Murphy
Mathematical models are routinely applied to interpret biological data, with common goals that include both prediction and parameter estimation. A challenge in mathematical biology…