87 citations · 180 across the 6 of their papers we have counts for
4 papers · 1 filter
Lymphotactin: how a protein can adopt two folds
Carlo Camilloni, Ludovico Sutto
Metamorphic proteins like Lymphotactin are a notable exception of the empirical principle that structured natural proteins possess a unique three dimensional structure. In particul…
Hierarchy of events in protein folding: beyond the Go model
Ludovico Sutto, Guido Tiana, Ricardo A. Broglia
Simplified Go models, where only native contacts interact favorably, have proven useful to characterize some aspects of the folding of small proteins. The success of these models i…
Design of amino acid sequences to fold into C_alpha-model proteins
A. Amatori, G. Tiana, L. Sutto +3
In order to extend the results obtained with minimal lattice models to more realistic systems, we study a model where proteins are described as a chain of 20 kinds of structureless…
Design of HIV-1-PR inhibitors which do not create resistance: blocking the folding of single monomers
R. A. Broglia, G. Tiana, L. Sutto +2
One of the main problems of drug design is that of optimizing the drug--target interaction. In the case in which the target is a viral protein displaying a high mutation rate, a se…