1 citations · 1 across the 2 of their papers we have counts for
6 papers
Design of HIV-1-PR inhibitors which do not create resistance: blocking the folding of single monomers
R. A. Broglia, G. Tiana, L. Sutto +2
One of the main problems of drug design is that of optimizing the drug--target interaction. In the case in which the target is a viral protein displaying a high mutation rate, a se…
Understanding the determinants of stability and folding of small globular proteins from their energetics
G. Tiana, F. Simona, G. M. S. De Mori +2
The results of minimal model calculations suggest that the stability and the kinetic accessibility of the native state of small globular proteins are controlled by few "hot" sites.…
Design and Folding of Dimeric Proteins
G. Tiana, R. A. Broglia
In a similar way in which the folding of single--domain proteins provide an important test in the study of self--organization, the folding of homodimers constitute a basic challeng…
Reading the three-dimensional structure of a protein from its amino acid sequence
R. A. Broglia, G. Tiana
While all the information required for the folding of a protein is contained in its amino acid sequence, one has not yet learnt how to extract this information so as to predict the…
Why does a protein fold?
R. A. Broglia, G. Tiana
With the help of lattice Monte Carlo modelling of heteropolymers, we show that the necessary condition for a protein to fold on short call is to proceed through partially folded in…
Protein Foldability and Designability: General Physics and Pretty Chemistry
R. A. Broglia, G. Tiana, H. E. Roman
Making use of a simplified model for protein folding, it can be shown that conformations which are particularly stable when their energy is minimized with respect to amino acid seq…