205 citations · 452 across the 18 of their papers we have counts for
18 papers
Multistable protocells can aid the evolution of prebiotic autocatalytic sets
Angad Yuvraj Singh, Sanjay Jain
We present a simple mathematical model that captures the evolutionary capabilities of a prebiotic compartment or protocell. In the model the protocell contains an autocatalytic set…
Feedbacks from the metabolic network to the genetic network reveal regulatory modules in E. coli and B. subtilis
Santhust Kumar, Saurabh Mahajan, Sanjay Jain
The genetic regulatory network (GRN) plays a key role in controlling the response of the cell to changes in the environment. Although the structure of GRNs has been the subject of…
Flux-based classification of reactions reveals a functional bow-tie organization of complex metabolic networks
Shalini Singh, Areejit Samal, Varun Giri +3
Unraveling the structure of complex biological networks and relating it to their functional role is an important task in systems biology. Here we attempt to characterize the functi…
The origin of large molecules in primordial autocatalytic reaction networks
Varun Giri, Sanjay Jain
Large molecules such as proteins and nucleic acids are crucial for life, yet their primordial origin remains a major puzzle. The production of large molecules, as we know it today,…
Flows in complex biochemical networks: Role of low degree nodes
Areejit Samal, Sanjay Jain
Metabolic networks have two properties that are generally regarded as unrelated: One, they have metabolic reactions whose single knockout is lethal for the organism, and two, they…
Diversity Begets Stability in an Evolving Network
Ravi Mehrotra, Vikram Soni, Sanjay Jain
Complex evolving systems such as the biosphere, ecosystems and societies exhibit sudden collapses, for reasons that are only partially understood. Here we study this phenomenon usi…