209 citations · 1.3k across the 28 of their papers we have counts for
28 papers
Conditions for Darwinian evolution in compartmentalized autocatalytic reaction networks
Yoshiya J. Matsubara, Sandeep Ameta, Shashi Thutupalli +2
The first forms of life likely consisted of protocells endowed with metabolism, growth, and division. Such systems may have evolved due to variation and heredity in their chemical…
Flux-based classification of reactions reveals a functional bow-tie organization of complex metabolic networks
Shalini Singh, Areejit Samal, Varun Giri +3
Unraveling the structure of complex biological networks and relating it to their functional role is an important task in systems biology. Here we attempt to characterize the functi…
Switching between oscillations and homeostasis in competing negative and positive feedback motifs
Weihan Li, Sandeep Krishna, Simone Pigolotti +2
We analyze a class of network motifs in which a short, two-node positive feed- back motif is inserted in a three-node negative feedback loop. We demonstrate that such networks can…
Inducing phase-locking and chaos in cellular oscillators by modulating the driving stimuli
Mogens H. Jensen, Sandeep Krishna
Inflammatory responses in eucaryotic cells are often associated with oscillations in the nuclear-cytoplasmic translocation of the transcription factor NF-kB. In most laboratory rea…
Dickkopf1 - a new player in modelling the Wnt pathway
Lykke Pedersen, Sandeep Krishna, Mogens H. Jensen
The Wnt signalling pathway transducing the stabilization of beta-catenin is essential for metazoan embryo development and is misregulated in many diseases such as cancers. In recen…
Toolbox model of evolution of prokaryotic metabolic networks and their regulation
Sergei Maslov, Sandeep Krishna, Tin Yau Pang +1
It has been reported that the number of transcription factors encoded in prokaryotic genomes scales approximately quadratically with their total number of genes. We propose a conce…