156 citations · 650 across the 32 of their papers we have counts for
18 papers · 1 filter
IMPPAT 3.0: An updated FAIR database of phytochemicals and formulations of Indian Medicinal plants
Shanmuga Priya Baskaran, Ajaya Kumar Sahoo, Priyotosh Sil +6
Ayurvedic formulations represent a rich source of traditional knowledge, encompassing distinct therapeutic approaches, medicinal ingredients, and underlying principles of drug acti…
Computational investigation of single herbal drugs in Ayurveda for diabetes and obesity using knowledge graph and network pharmacology
Priyotosh Sil, Rahul Tiwari, Vasavi Garisetti +4
Metabolic diseases such as type 2 diabetes and obesity represent a rapidly escalating global health burden, yet current therapeutic strategies largely target isolated symptoms or s…
Systematic evaluation of a new combinatorial curvature for complex networks
R. P. Sreejith, Jürgen Jost, Emil Saucan +1
We have recently introduced Forman's discretization of Ricci curvature to the realm of complex networks. Forman curvature is an edge-based measure whose mathematical definition ele…
Forman curvature for directed networks
R. P. Sreejith, Jürgen Jost, Emil Saucan +1
A goal in network science is the geometrical characterization of complex networks. In this direction, we (arXiv:1603.00386; J. Stat. Mech. (2016) P063206) have recently introduced…
Forman curvature for complex networks
R. P. Sreejith, Karthikeyan Mohanraj, Jürgen Jost +2
We adapt Forman's discretization of Ricci curvature to the case of undirected networks, both weighted and unweighted, and investigate the measure in a variety of model and real-wor…
Phenotypic constraints promote latent versatility and carbon efficiency in metabolic networks
Marco Bardoscia, Matteo Marsili, Areejit Samal
System-level properties of metabolic networks may be the direct product of natural selection or arise as a by-product of selection on other properties. Here we study the effect of…
Relative Stability of Network States in Boolean Network Models of Gene Regulation in Development
Joseph Xu Zhou, Areejit Samal, Aymeric Fouquier d'Hèrouël +2
Progress in cell type reprogramming has revived the interest in Waddington's concept of the epigenetic landscape. Recently researchers developed the quasi-potential theory to repre…
Analysis of the hierarchical structure of the B. subtilis transcriptional regulatory network
Santhust Kumar, Michele Vendruscolo, Amit Singh +2
The transcriptional regulation of gene expression is orchestrated by complex networks of interacting genes. Increasing evidence indicates that these transcriptional regulatory netw…
Flux-based classification of reactions reveals a functional bow-tie organization of complex metabolic networks
Shalini Singh, Areejit Samal, Varun Giri +3
Unraveling the structure of complex biological networks and relating it to their functional role is an important task in systems biology. Here we attempt to characterize the functi…
Environmental versatility promotes modularity in genome-scale metabolic networks
Areejit Samal, Andreas Wagner, Olivier C. Martin
The ubiquity of modules in biological networks may result from an evolutionary benefit of a modular organization. For instance, modularity may increase the rate of adaptive evoluti…
Flows in complex biochemical networks: Role of low degree nodes
Areejit Samal, Sanjay Jain
Metabolic networks have two properties that are generally regarded as unrelated: One, they have metabolic reactions whose single knockout is lethal for the organism, and two, they…
Randomizing genome-scale metabolic networks
Areejit Samal, Olivier C. Martin
Networks coming from protein-protein interactions, transcriptional regulation, signaling, or metabolism may appear to have "unusual" properties. To quantify this, it is appropriate…
Genotype networks in metabolic reaction spaces
Areejit Samal, Joao F. Matias Rodrigues, Jürgen Jost +2
Background: A metabolic genotype comprises all chemical reactions an organism can catalyze via enzymes encoded in its genome. A genotype is viable in a given environment if it is c…
Conservation of high-flux backbone in alternate optimal and near-optimal flux distributions of metabolic networks
Areejit Samal
Constraint-based flux balance analysis (FBA) has proven successful in predicting the flux distribution of metabolic networks in diverse environmental conditions. FBA finds one of t…
Study of the structure and dynamics of complex biological networks
Areejit Samal
In this thesis, we have studied the large scale structure and system level dynamics of certain biological networks using tools from graph theory, computational biology and dynamica…
The regulatory network of E. coli metabolism as a boolean dynamical system exhibits both homeostasis and flexibility of response
Areejit Samal, Sanjay Jain
Elucidating the architecture and dynamics of large scale genetic regulatory networks of cells is an important goal in systems biology. We study the system level dynamical propertie…
Evidence of a universal power law characterizing the evolution of metabolic networks
Shalini, Areejit Samal, Varun Giri +3
Metabolic networks are known to be scale free but the evolutionary origin of this structural property is not clearly understood. One way of studying the dynamical process is to com…
Low Degree Metabolites Explain Essential Reactions and Enhance Modularity in Biological Networks
Areejit Samal, Shalini Singh, Varun Giri +3
Recently there has been a lot of interest in identifying modules at the level of genetic and metabolic networks of organisms, as well as in identifying single genes and reactions t…