240 citations · 1k across the 30 of their papers we have counts for
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Modeling of the genetic switch of bacteriophage TP901-1: A heteromer of CI and MOR ensures robust bistability
Hiizu Nakanishi, Margit Pedersen, Anne K. Alsing +1
The lytic-lysogenic switch of the temperate lactococcal phage TP901-1 is fundamentally different from that of phage lambda. In phage TP901-1, the lytic promoter PL is repressed by…
Dynamical Analysis on Gene Activity in the Presence of Repressors and an Interfering Promoter
Hiizu Nakanishi, Namiko Mitarai, Kim Sneppen
Transcription is regulated through interplay between transcription factors, an RNA polymerase(RNAP), and a promoter. Even for a simple repressive transcription factor that disturbs…
Cost and Capacity of Signaling in the Escherichia coli Protein Reaction Network
Jacob Bock Axelsen, Sandeep Krishna, Kim Sneppen
In systems biology new ways are required to analyze the large amount of existing data on regulation of cellular processes. Recent work can be roughly classified into either dynamic…
Oscillations and temporal signalling in cells
G. Tiana, S. Krishna, S. Pigolotti +2
The development of new techniques to quantitatively measure gene expression in cells has shed light on a number of systems that display oscillations in protein concentration. Here…
UV-induced mutagenesis in Escherichia coli SOS response: A quantitative model
Sandeep Krishna, Sergei Maslov, Kim Sneppen
Escherichia coli bacteria respond to DNA damage by a highly orchestrated series of events known as the SOS response, regulated by transcription factors, protein-protein binding and…
Propagation of fluctuations in interaction networks governed by the law of mass action
Sergei Maslov, Kim Sneppen, Iaroslav Ispolatov
Using an example of physical interactions between proteins, we study how perturbations propagate in interconnected networks whose equilibrium state is governed by the law of mass a…