Showing stat.MEShow all
3 papers · 1 filter
stat.ME2026
A Targeted Learning Framework for Estimating Restricted Mean Survival Time Difference using Pseudo-observations
Man Jin, Yixin Fang
A targeted learning (TL) framework is developed to estimate the difference in the restricted mean survival time (RMST) for a clinical trial with time-to-event outcomes. The approac…
stat.ME2025
Estimand framework and intercurrent events handling for clinical trials with time-to-event outcomes
Yixin Fang, Man Jin
The ICH E9(R1) guideline presents a framework of estimand for clinical trials, proposes five strategies for handling intercurrent events (ICEs), and provides a comprehensive discus…
stat.ME2024
Statistical Inference for Chi-square Statistics or F-Statistics Based on Multiple Imputation
Binhuan Wang, Yixin Fang, Man Jin
Missing data is a common issue in medical, psychiatry, and social studies. In literature, Multiple Imputation (MI) was proposed to multiply impute datasets and combine analysis res…